期刊
TRANSCRIPTION-AUSTIN
卷 5, 期 4, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/21541272.2014.944014
关键词
development; differentiation; disease; gene expression; long non-coding RNAs; skeletal muscle
资金
- NCI NIH HHS [P01 CA104106, T32 CA009109] Funding Source: Medline
- NIAMS NIH HHS [R01 AR053948] Funding Source: Medline
A significant portion of the mammalian genome encodes numerous transcripts that are not translated into proteins, termed long non-coding RNAs. Initial studies identifying long non-coding RNAs inferred these RNA sequences were a consequence of transcriptional noise or promiscuous RNA polymerase II activity. However, the last decade has seen a revolution in the understanding of regulation and function of long non-coding RNAs. Now it has become apparent that long non-coding RNAs play critical roles in a wide variety of biological processes. In this review, we describe the current understanding of long non-coding RNA-mediated regulation of cellular processes: differentiation, development, and disease.
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