期刊
JOURNAL OF SUPERCRITICAL FLUIDS
卷 136, 期 -, 页码 29-36出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.supflu.2018.01.030
关键词
Supercritical carbon dioxide; PMMA; Selective laser sintering; Drug impregnation; Biocomposites
资金
- National Science Foundation Research Experience for Undergraduates program [1460645]
- AI.SAM Foundation
- Institute of International Education
- University of San Diego Associated Students and Engineering Research Funds
Multi-functional biocomposites were developed using a 3D-printing method coupled with supercritical carbon dioxide (scCO(2)) processing. Selective laser sintering was used to prepare poly(methyl methacrylate)/beta-tri-calcium phosphate biocomposites, which were subsequently treated with an anti-inflammatory drug (flurbiprofen) in scCO(2). Drug impregnation behaviors were investigated under different temperatures and pressures (313 K and 323 K; 85-115 bar). Results show that drug molecules were able to diffuse into the biocomposite structure effectively, achieving > 26% by weight of drug uptake. Surface morphology of the materials remained unaffected upon pro-longed scCO(2) processing. Drug release data was modeled using the Weibull function, indicating potential influences of scCO(2) processing temperature on the PMMA surface and the interaction between flurbiprofen particles and PMMA matrix inside the composite structure.
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