期刊
JOURNAL OF SUPERCRITICAL FLUIDS
卷 140, 期 -, 页码 11-20出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.supflu.2018.05.025
关键词
Supercritical carbon dioxide impregnation; Pseudomonas aeruginosa; Staphylococcus aureus; Cellulose acetate; Thymol
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [11145017, 01173048]
This study discusses utilization of supercritical carbon dioxide for impregnation of cellulose acetate films with thymol in order to produce material with anti-biofilm activity against Pseudomonas aeruginosa and Staphylococcus aureus. Analysis of anti-biofilm activity of cellulose acetate beads impregnated with thymol suggested that optimal thymol loading was in the range from 26% to 30% for efficient reduction of biofilm formation and eradication of pre-formed biofilms. Polymer films were fabricated by the solvent casting method from polymer solutions of different contents, and loaded with thymol using supercritical carbon dioxide at 15.5 MPa and 35 degrees C. The film containing 30% of thymol (F1 30%) exhibited substantial anti-adhesion properties inhibiting biofilm formation on its surface and considerably reduced formation of biofilms on the surrounding surfaces (up to 80%) by all tested strains including antibiotic resistant P. aeruginosa DM50 and methicillin-resistant S. aureus.
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