4.4 Article

Effects of Endurance Exercise Bouts in Hypoxia, Hyperoxia, and Normoxia on mTOR-Related Protein Signaling in Human Skeletal Muscle

期刊

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
卷 34, 期 8, 页码 2276-2284

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1519/JSC.0000000000002753

关键词

ambient oxygen conditions; one-legged cycling; muscular adaptation signaling; m; vastus lateralis

资金

  1. Federal Institute of Sport Sciences (BISp), Germany
  2. German Sport University Cologne, Germany

向作者/读者索取更多资源

Przyklenk, A, Aussieker, T, Gutmann, B, Schiffer, T, Brinkmann, C, Struder, HK, Bloch, W, Mierau, A, and Gehlert, S. Effects of endurance exercise bouts in hypoxia, hyperoxia, and normoxia on mTOR-related protein signaling in human skeletal muscle.J Strength Cond Res34(8): 2276-2284, 2020-This study investigated the effects of short-term hypoxia (HY), hyperoxia (PER), and normoxia on anabolic signaling proteins in response to an acute bout of moderate endurance exercise (EEX) before and after an endurance exercise training intervention. Eleven healthy male subjects conducted one-legged cycling endurance exercise (3 x 30 min center dot wk(-1)for 4 weeks). One leg was trained under hypoxic (12% O-2) or hyperoxic conditions (in a randomized cross-over design), and the other leg was trained in normoxia (20.9% O-2) at the same relative workload. Musculus vastus lateralis biopsies were taken at baseline (T0) as well as immediately after the first (T1) and last (T2) training session to analyze anabolic signaling proteins and the myofiber cross-sectional area (FCSA). No significant differences were detected for FCSA between T0 and T2 under all oxygen conditions (p> 0.05). No significant differences (p> 0.05) were observed for BNIP3, phosphorylated RSK1, ERK1/2, FoxO3a, mTOR, and S6K1 between all conditions and time points. Phosphorylated Akt/PKB decreased significantly (p< 0.05) at T1 in PER and at T2 in HY and PER. Phosphorylated rpS6 decreased significantly (p< 0.05) at T1 only in PER, whereas nonsignificant increases were shown in HY at T2 (p= 0.10). Despite no significant regulations, considerable reductions in eEF2 phosphorylation were detected in HY at T1 and T2 (p= 0.11 andp= 0.12, respectively). Short-term hypoxia in combination with moderate EEX induces favorable acute anabolic signaling responses in human skeletal muscle.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据