期刊
GYNECOLOGIC ONCOLOGY
卷 139, 期 3, 页码 506-512出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2015.07.015
关键词
Cervical cancer; Radiation; Chemoradiation; Chemosensitization; Volume; Outcomes
资金
- National Cancer Institute [NCI R01CA169121-01A1, NCI R01 CA166084, NCI R25 CA094061-11]
Objective. Procedural volume is associated with outcomes for many surgical interventions. Little is known about the association between volume and outcomes of radiation. We examined the association between treatment center and hospital volume and outcomes for women with locally advanced cervical cancer treated with radiation. Methods. Women with stage IIB-IVA cervical cancer treated with primary radiation from 1998 to 2011 and recorded in the National Cancer Database were examined. Hospital volume was estimated as the mean annualized volume, while center-specific effects on care were examined using a hospital-specific random effect. Multivariable regression models adjusted for metrics of treatment quality were used to estimate survival. Results. 20,766 patients treated at 1115 hospitals were identified. The median follow-up was 24.2 months while 5-year survival was 36.5% (95% CI, 35.6-37.4%). Higher hospital volume was associated with receipt of brachytherapy (P < 0.05), but had no effect on use of chemotherapy. In a multivariable model accounting for clinical and demographic factors as well as quality of care, hospital volume was not associated with survival (P = 0.25). The specific hospital in which patients received care was the strongest predictor of survival (P < 0.0001) followed by stage, year of diagnosis and treatment quality (P < 0.0001 for all). The hospital-specific effect on mortality expressed as a hazard ratio, ranged from 0.66 to 1.53 across hospitals. Conclusion. For locally advanced cervical cancer, hospital volume has a minimal impact on outcome; however, the specific center in which care is delivered is strongly associated with survival. (C) 2015 Elsevier Inc. All rights reserved.
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