期刊
JOURNAL OF SEPARATION SCIENCE
卷 41, 期 13, 页码 2750-2758出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.201800235
关键词
cream samples; liquid chromatography; matrix solid-phase dispersion; parabens; supramolecular solvents
资金
- Bulent Ecevit University [BAP-2016-72118496-06]
An analytical method is presented for the determination of paraben preservatives in semisolid cream samples by matrix solid-phase dispersion combined with supramolecular solvent-based microextraction. Due to the oily and sticky nature of the sample matrix, parabens were first extracted from the samples by matrix solid-phase dispersion using silica as sorbent material with a clean-up performed with tetrahydrofuran in the elution step. The eluate (500 mu L), 1-decanol (120 mu L), and water (4.4 mL) were then mixed in a polyethylene pipette to form supramolecular solvent. Finally, the analytes in the supramolecular solvent were separated and determined by liquid chromatography with ultraviolet detection. Under optimal extraction conditions, the extraction recoveries of the studied compounds were obtained in the range of 63-83%. The limits of detection for the analytes were between 0.03 and 0.04 mu g/g. The precision of the method varied between 4.0-6.7 (intraday) and 6.2-7.9% (interday). Finally, the optimized procedure was applied to the determination of the target preservatives in a variety of cream samples (diaper rash, skin allergy, face and hand moisturizing) with satisfactory recoveries (86-102%).
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