期刊
GYNECOLOGIC ONCOLOGY
卷 138, 期 3, 页码 573-578出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2015.06.040
关键词
ASC-US; HPV testing; Cervical screening; Triage
Background. In US cervical screening, immediate colposcopy is recommended for women with HPV-positive ASC-US (equivocal) cytology. We evaluated whether partial typing by Onclarity (TM) (BD) might identify HPV-positive women with low enough CIN3+ risk to permit 1-year follow-up instead. Methods. The NCI-Kaiser Permanente Northern California Persistence and Progression cohort includes a subset of 13,890 women aged 21+ with HC2 (Qiagen)-positive ASC-US at enrollment; current median follow-up is 3.0 years. Using stratified random sampling, we typed 2079 archived enrollment specimens including 329 women subsequently diagnosed with CIN3 +, 563 with CIN2, and 1187 with
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