期刊
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
卷 306, 期 2, 页码 F147-F154出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.00378.2013
关键词
acute kidney injury; biomarkers; cisplatin; megalin; nephrotoxins
资金
- Lundbeck Foundation
- Danish Medical Research Council
- Fonden til Laegevidenskabens Fremme
- Novo Nordisk Foundation
The kidney proximal tubule is a key target in many forms of acute kidney injury (AKI). The multiligand receptor megalin is responsible for the normal proximal tubule uptake of filtered molecules, including nephrotoxins, cytokines, and markers of AKI. By mediating the uptake of nephrotoxins, megalin plays an essential role in the development of some types of AKI. However, megalin also mediates the tubular uptake of molecules implicated in the protection against AKI, and changes in megalin expression have been demonstrated in AKI in animal models. Thus, modulation of megalin expression in response to AKI may be an important part of the tubule cell adaption to cellular protection and regeneration and should be further investigated as a potential target of intervention. This review explores current evidence linking megalin expression and function to the development, diagnosis, and progression of AKI as well as renal protection against AKI.
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