期刊
JOURNAL OF PROTEOMICS
卷 191, 期 -, 页码 48-57出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jprot.2018.04.021
关键词
Tumor antigens; Mass spectrometry; Next generation sequencing; Bioinformatics; Cancer immunology
The field of cancer immunotherapy has expanded rapidly in the past few years, with many new approaches entering the clinic for T cell mediated killing of tumors. Several of these clinical approaches involve the exploitation of a CD8 + T cell response against MHC I presented tumor antigens. Here, we describe the types of tumor antigens which are considered as targets in the design of T cell based therapeutic approaches, the rationale for targeting MHC I antigens and the analytical tools commonly employed for the discovery of MHC I presented peptides. The advantages and disadvantages of each approach are discussed and a perspective on the future directions of the MHC I peptide exploration field and biotherapeutic strategies is given. Significance: This work is the first time a review article has been written to summarize all the various types of tumor antigens, and the analytical tools employed to discover and characterize them.
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