期刊
JOURNAL OF PROTEOME RESEARCH
卷 17, 期 12, 页码 4325-4328出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.8b00384
关键词
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资金
- PE I+D+i 2013-2016 [PT17/0019]
- ISCIII
- ERDF
Currently, 14% of the human proteome is made up of proteins whose existence is not confirmed by mass spectrometry. We performed a proteomic profiling of human mesenchymal stem cells derived from adipose tissue or umbilical cord (PRIDE accession number: PXD009893) and identified peptides derived from 13 of such missing proteins. Remarkably, we found compelling evidence of the expression of hyaluronan synthase 1 (NX_Q92839-1) and confirmed its identification by the fragmentation of four heavy-labeled peptides that coeluted with their endogenous light counterparts. Our data also suggest that mesenchymal stem cells constitute a promising source for the detection of missing proteins.
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