期刊
JOURNAL OF PROTEOME RESEARCH
卷 17, 期 3, 页码 1321-1325出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jproteome.7b00851
关键词
standard; proteoform; human readable; machine readable
资金
- Computation and Informatics in Biology and Medicine Training Program [T15LM007359]
- National Institute for General Medical Sciences [P41 GM108569]
- EuBIC initiative, ELIXIR Denmark
- Danish Research Council
- National Institute of General Medical Sciences [R01GM114292]
- ELIXIR
- EMBL core funds
The Consortium for Top-Down Proteomics (CTDP) proposes a standardized notation, ProForma, for writing the sequence of fully characterized proteoforms. ProForma provides a means to communicate any proteoform by writing the amino acid sequence using standard one-letter notation and specifying modifications or unidentified mass shifts within brackets following certain amino acids. The notation is unambiguous, human readable, and can easily be parsed and written by bioinformatic tools. This system uses seven rules and supports a wide range of possible use cases, ensuring compatibility and reproducibility of proteoform annotations. Standardizing proteoform sequences will simplify storage, comparison, and reanalysis of proteomic studies, and the Consortium welcomes input and contributions from the research community on the continued design and maintenance of this standard.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据