期刊
JOURNAL OF POLYMER RESEARCH
卷 25, 期 5, 页码 -出版社
SPRINGER
DOI: 10.1007/s10965-018-1499-1
关键词
Chitosan; Magnetite iron oxide nanoparticle; Drug delivery; Nanocomposite hydrogel
资金
- Karaj Islamic Azad University
- PNU
- INSF
Over the last decade, nanocomposite hydrogels have been provided a new approach for the biomedical field. In this work, a novel pH-responsive nanocomposite hydrogel was fabricated using simultaneous in situ formation of magnetite iron oxide nanoparticles and hydrogel networks of poly(acrylic acid) grafted onto chitosan. The effects of various types of precursor molecules, pH, salt, and loading pressure were examined on the swelling properties of resulting nanocomposite hydrogels. The synthesized nanocomposite hydrogel was well characterized using different instruments. In vitro drug releasing behavior of doxorubicin was studied at pH 5.4 and 7.4. The drug release mechanism was investigated through different kinetic models. These experimental results open a new opportunity to make pH-responsive nanocomposite hydrogel devices for controlled delivery of drug.
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