期刊
JOURNAL OF IMMUNOLOGY
卷 192, 期 5, 页码 2010-2014出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.1126/science.8171322
关键词
-
类别
Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4(+)CD8(-) and CD4(-)CD8(+) T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据