期刊
CURRENT DERMATOLOGY REPORTS
卷 3, 期 1, 页码 61-78出版社
SPRINGER
DOI: 10.1007/s13671-013-0066-6
关键词
Psoriasis; Genetic; Prevalence; Epidemiology; Pathogenesis
类别
资金
- NIAMS NIH HHS [K08 AR057763, R01 AR065174] Funding Source: Medline
Psoriasis is a chronic, inflammatory, immune-mediated skin condition with a prevalence of 0-11.8 % across the world. It is associated with a number of cardiovascular, metabolic, and autoimmune disease comorbidities. Psoriasis is a multifactorial disorder, influenced by both genetic and environmental factors. Its genetic basis has long been established through twin studies and familial clustering. The association of psoriasis with the HLA-Cw6 allele has been shown in many studies. Recent genome-wide association studies have identified a large number of other genes associated with psoriasis. Many of these genes regulate the innate and adaptive immune system. These findings indicate that a dysregulated immune system may play a major role in the pathogenesis of psoriasis. In this article, we review the clinical and genetic epidemiology of psoriasis with a brief description of the pathogenesis of disease.
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