期刊
BLOOD RESEARCH
卷 49, 期 1, 页码 29-35出版社
KOREAN SOC HEMATOLOGY
DOI: 10.5045/br.2014.49.1.29
关键词
Pediatric acute lymphoblastic leukemia; Hyperleukocytosis; Central nervous system hemorrhage
类别
资金
- Pusan National University
Background Hyperleukocytosis caused by acute lymphoblastic leukemia (ALL) is associated with early morbidity and mortality due to hyperviscosity arising from the excessive number of leukocytes. This study was designed to assess the incidence of hyperleukocytosis, survival outcomes, and adverse features among pediatric ALL patients with hyperleukocytosis. Methods Between January 2001 and December 2010, 104 children with previously untreated ALL were enrolled at the Pusan National University Hospital. All of them were initially stratified based on the National Cancer Institute (NCI) risk; 48 (46.2%) were diagnosed with high-risk ALL. The medical charts of these patients were retrospectively reviewed. Results Twenty (19.2%) of the 104 children with ALL had initial leukocyte counts of > 100x10(9)/L, and 11 patients had a leukocyte count of > 200x10(9)/L. Male gender, T-cell phenotype, and massive splenomegaly were positively associated with hyperleukocytosis. Common early complications during induction therapy included renal dysfunction, and central nervous system hemorrhage. The complete remission (CR) rate for the pediatric ALL patients with hyperleukocytosis (94.1%) was similar to the overall CR rate (95.6%). The estimated 3-year event free survival (EFS) and overall survival of ALL children with hyperleukocytosis were 75.0% and 81.2%, respectively. However, patients with initial leukocyte counts > 200x10(9)/L had a lower EFS than those with initial leukocyte counts 100. 200x10(9)/L (63.6% vs. 100%; P=0.046). Conclusion The outcome of pediatric ALL cases with an initial leukocyte count > 200x10(9)/L was very poor, probably due to early toxicity-related death during induction therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据