期刊
JOURNAL OF PHYSIOLOGICAL SCIENCES
卷 69, 期 1, 页码 13-21出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12576-018-0607-7
关键词
Spinal cord; Neurovascular coupling; Pain; Nociception; Blood flow; Local field potential
类别
资金
- Natural Sciences and Engineering Research Council of Canada [402176, 05403]
Neurological examination remains the primary clinical investigation in patients with spinal cord injury. However, neuroimaging methods such as functional magnetic resonance imaging (fMRI) are promising tools for following functional changes in the course of injury, disease and rehabilitation. However, the relationship between neuronal activity and blood flow in the spinal cord on which fMRI relies has been largely overlooked. The objective of this study was to examine neurovascular coupling in the spinal cord of decerebrated rats during electrical stimulation of the sciatic nerve with and without isoflurane anesthesia (1.2%). Local field potentials (LFP) and spinal cord blood flow (SCBF) were recorded simultaneously in the lumbosacral enlargement. Isoflurane did not significantly alter LFP (p=0.53) and SCBF (p=0.57) amplitude. Accordingly, neurovascular coupling remained comparable with or without isoflurane anesthesia (p=0.39). These results support the use of isoflurane in rodents to investigate nociceptive functions of the spinal cord using fMRI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据