期刊
EMERGING INFECTIOUS DISEASES
卷 20, 期 3, 页码 372-379出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2003.131159
关键词
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资金
- Intergovernmental Hendra Virus Taskforce
- Zoetis Research Manufacturing
- CSIRO in Australia
- US Department of Health and Human Services, National Institutes of Health [AI054715, AI077995]
In recent years, the emergence of several highly pathogenic zoonotic diseases in humans has led to a renewed emphasis on the interconnectedness of human, animal, and environmental health, otherwise known as One Health. For example, Hendra virus.(HeV), a zoonotic paramyxovirus, was discovered in 1994, and since then, infections have occurred in 7 humans, each of whom had a strong epidemiologic link to similarly affected horses. As a consequence of these outbreaks, eradication of bat populations was discussed, despite their crucial environmental roles in pollination and reduction of the insect population. We describe the development and evaluation of a vaccine for horses with the potential for breaking the chain of HeV transmission from bats to horses to humans, thereby protecting horse, human, and environmental health. The HeV vaccine for horses is a key example of a One Health approach to the control of human disease.
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