期刊
PATHOGENS
卷 3, 期 1, 页码 1-13出版社
MDPI
DOI: 10.3390/pathogens3010001
关键词
skin; hand; microbiome; microbiota; hand hygiene; healthcare; pathogen
类别
资金
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [T32 AI049816]
- Robert Wood Johnson Foundation Health & Society Scholars (RWJF HSS) Small Grants Program [N012550-399789]
- University of Michigan Rackham Graduate Student Research Grant
- University of Michigan School of Public Health Department of Epidemiology
One function of skin microbiota is to resist colonization and infection by external microorganisms. We sought to detect whether the structure of the hand microbiota of 34 healthcare workers (HCW) in a surgical intensive care unit mediates or modifies the relationship between demographic and behavioral factors and potential pathogen carriage on hands after accounting for pathogen exposure. We used a taxonomic screen (16S rRNA) to characterize the bacterial community, and qPCR to detect presence of Staphylococcus aureus, Enterococcus spp., methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans on their dominant hands. Hands were sampled weekly over a 3-week period. Age, hand hygiene, and work shift were significantly associated with potential pathogen carriage and the associations were pathogen dependent. Additionally, the overall hand microbiota structure was associated with the carriage of potential pathogens. Hand microbiota community structure may act as a biomarker of pathogen carriage, and modifying that structure may potentially limit pathogen carriage among HCW.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据