期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
卷 186, 期 -, 页码 131-136出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2018.07.004
关键词
Nanoparticles; Metal oxide; Kidney tumor; Phyto medium; Cell viability
资金
- National Natural Science Foundation of China [81700664]
- Shandong Provincial Natural Science Foundation, China [ZR2016HP38]
- Projects of medical and health technology development program in Shandong Province [2016WS0714]
- Science and Technology Project of Yantai [2016WS018]
Cancer in human society is one of the most problematic health issue responsible for outnumbered deaths worldwide. The consumption of developed NPs in cancer diagnosis is a rapidly emerging field of bio-medical nanotechnology. Recent years, greener synthesized metal oxide hybrid nanoparticles have attracted great attention in cytotoxicity to different cancer therapy. Herein, we report that Duchesnea indica plant mediated green synthesis plant extract mediated Zn doped CuO (Zn/CuO) nanoparticles (NPs) prepared by hydrothermal method and these physico-chemical properties were characterized by XRD, UV-DRS, FTIR, and SEM with EDAX analytical techniques. The XRD pattern findings indicated that the crystal structure of the base CuO matrix are not distorted by the substitution of Cu2+ (0.73 angstrom) ions by Zn-2(+) (0.65 angstrom) ions. The average crystallite size of undoped and Zn/CuO NPs samples are found to be in between the range of 23 to 36 nm. And we can see that the Zn/CuO NPs are large aggregates, containing small particles with sizes of 100-300 nm with spherical shaped morphology by SEM and TEM microscopic images. The normal cell viability and cancer cell inhibition results on A-498 cancer cells and also normal human epithelial cells exhibited that no significant changes in the cell viability with normal kidney epithelial cells and doped NPs given excellent cell inhibition treated on A-498 kidney tumor cells.
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