期刊
JOURNAL OF PEDIATRICS
卷 198, 期 -, 页码 67-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2018.03.028
关键词
-
类别
资金
- National Institutes of Health (NIH) [K23 DK085150]
- NIH/NCATS Colorado CTSA [UL1TR001082]
Objective To determine the effects of treating obstructive sleep apnea/nocturnal hypoxia on pediatric nonalcoholic fatty liver disease (NAFLD) severity and oxidative stress. Study design Biopsy proven participants (n = 9) with NAFLD and obstructive sleep apnea/hypoxia were studied before and after treatment with continuous positive airway pressure (CPAP) for sleep disordered breathing, including laboratory testing and markers of oxidative stress, urine F(2)-isoprostanes. Results Adolescents (age 11.5 +/- 1.2 years; body mass index, 29.5 +/- 3.8 kg/m(2)) with significant NAFLD (mean histologic necroinflammation grade, 2.3 +/- 0.9; fibrosis stage, 1.4 +/- 1.3; NAFLD Activity Score summary, 4.8 +/- 1.6) had obstructive sleep apnea/hypoxia by polysomnography. At baseline, they had severe obstructive sleep apnea/hypoxia, elevated aminotransferases, the metabolic syndrome, and significant oxidative stress (high F(2)-isoprostanes). Obstructive sleep apnea/hypoxia was treated with home CPAP for a mean 89 +/- 62 days. Although body mass index increased, obstructive sleep apnea/hypoxia severity improved on CPAP and was accompanied by reduced alanine aminotransferase, metabolic syndrome markers. and F(2)-isoprostanes. Conclusions This study provides strong evidence that treatment of obstructive sleep apnea/nocturnal hypoxia with CPAP in children with NAFLD may reverse parameters of liver injury and reduce oxidative stress. These data also suggest CPAP as a new therapy to prevent progression of NAFLD in those children with obesity found to have obstructive sleep apnea/nocturnal hypoxia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据