期刊
LUNG CANCER MANAGEMENT
卷 3, 期 2, 页码 159-173出版社
FUTURE MEDICINE LTD
DOI: 10.2217/LMT.14.12
关键词
DNA damage repair; drug resistance; genetic mutations; lung cancer; synthetic lethality
资金
- Cancer Council Queensland
Lung cancer is the leading cause of cancer-related mortality. According to WHO, 1.37 million deaths occur globally each year as a result of this disease. More than 70% of these cases are associated with prior tobacco consumption and/or cigarette smoking, suggesting a direct causal relationship. The development and progression of lung cancer and other malignancies involves the loss of genetic stability, resulting in acquisition of cumulative genetic changes; this affords the cell increased malignant potential. As such, an understanding of the mechanisms through which these events may occur will potentially allow for development of new anticancer therapies. This review will address the association between lung cancer and genetic instability, with a central focus on genetic mutations in the DNA damage repair pathways. In addition, we will discuss the potential clinical exploitation of these pathways, both in terms of biomarker staging, as well as through direct therapeutic targeting.
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