期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 16, 页码 9190-9200出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b01217
关键词
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资金
- NSFC [21772069]
- Natural Science Foundation of Jiangsu Province [BK20160003]
- Six Kinds of Talents Project of Jiangsu Province [SWYY-02S]
- TAPP
The first catalytic asymmetric construction of chiral dihydrobenzo[e]indole scaffolds has been established in a highly diastereo- and enantioselective mode (30 examples, up to 99% yield, >95:5 dr, >99% ee), which makes use of chiral phosphoric acid-catalyzed [3 + 2] cycloannulations of azonaphthalene derivatives with 3-vinylindoles. This reaction also represents the first catalytic asymmetric cycloannulation of azonaphthalene derivatives with alkenes, which will not only provide a useful method for constructing enantioenriched dihydrobenzo[e]indole scaffolds but also advance the chemistry of catalytic asymmetric reactions of azonaphthalene derivatives.
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