期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 15, 页码 8426-8448出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b01063
关键词
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资金
- Russian Science Foundation [18-13-00238]
- NIH Shared Instrumentation [S10RR024664]
- NSF Major Research Instrumentation [0329648]
Copper-catalyzed, directed addition of Grignard reagents across the strained C=C bond of cyclopropene-3-carboxamides was developed. It was demonstrated that the amide functionality serves as an ultimate directing group allowing for highly efficient control of diastereoselectivity of addition including stereoselectivity of electrophilic trapping with prochiral aldehydes. Also, regioselectivity of carbomagnesiation of cyclopropenes with a monosubstituted double bond is investigated. It was shown that in many cases this selectivity is controlled by steric factors and allows for preparation of products with a reversed regiochemistry.
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