期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 13, 页码 7215-7230出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00426
关键词
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资金
- Natural Sciences and Engineering Research Council
- University of Ottawa
The remarkable biological activities of polyprenylated polycyclic acylphloroglucinols (PPAPs) combined with their highly oxygenated and densely functionalized frameworks have stimulated the interest of synthetic organic chemists over the past decade. Herein, we report the concise total syntheses of four natural products PPAPs, of which some have antibacterial properties, notably hyperforin and papuaforin A. The salient features of this strategy are the short and gram-scalable synthesis of densely substituted PPAPs scaffolds via a Au(I)-catalyzed carbocyclization and the late stage functionalization for a unified access to a wide variety of PPAPs
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