期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 13, 页码 7281-7289出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00032
关键词
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资金
- JSPS KAKENHI [JP16H01161, JP16K05781]
- SUNBOR Grant from the Suntory Foundation for Life Sciences
- TOBE MAKI Scholarship Foundation
- Grants-in-Aid for Scientific Research [16H01161, 16K05781] Funding Source: KAKEN
The total synthesis of the 20 homogeneous members of mannosylerythritol lipids (MELs) with different alkyl chain lengths was effectively and systematically accomplished from a strategically designed common key intermediate that was stereoselectively constructed by the borinic acid catalyzed beta-mannosylation reaction. In addition, their antibacterial activities against Gram-positive bacteria were evaluated. Our results demonstrated that not only the length of the alkyl chains but also the pattern of Ac groups on the mannose moiety were important factors for antibacterial activity.
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