期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 2, 页码 1077-1083出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b02989
关键词
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资金
- National Natural Science Foundation of China [21625206, 21632009, 21372247, 21572258, 21572259, 21421002]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- Syngenta Ph.D. fellowship
- SIOC
A palladium-catalyzed difluoromethylation of a series of aryl chlorides and triflates under mild conditions was described. A variety of common functional groups were tolerated. In addition, by using this protocol, several drug molecules containing an aryl chloride unit were successfully difluoromethylated; thus enabling medicinal chemists to rapidly access novel drug derivatives with potentially improved properties via late-stage functionalization.
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