期刊
GROWTH FACTORS
卷 33, 期 2, 页码 92-101出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/08977194.2015.1010645
关键词
Autoimmune diseases; cancer; immune suppression; TGF-beta
Transforming growth factor-beta (TGF-beta) functions as an immune suppressor by influencing immune cells' development, differentiation, tolerance induction and homeostasis. In human diseases, TGF-beta has been revealed as an essential regulator of both innate and adaptive functions in autoimmune diseases. Furthermore, it plays a significant role in cancer by inhibiting immunosurveillance in the tumor-bearing host. A variety of TGF-beta neutralizing anticancer therapies have been investigated based on the role of TGF-beta in immunosuppression. New studies are focusing on combining TGF-beta blockade with tumor vaccinations and immunogene therapies.
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