期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 16, 页码 9278-9290出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b01245
关键词
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资金
- National Natural Science Foundation of China [21272024]
Squaramide-catalyzed asymmetric domino Michael/Mannich [3 + 2] cycloaddition reaction between rhodanine derivatives and N-(2,2,2-trifluoroethyl)isatin ketimines has been developed to synthesize various bispiro[oxindole-pyrrolidine-rhodanine]s with good to excellent yields (up to 99%) and excellent stereoselectivities (up to >99% ee and >99:1 dr). The biologically active rhodanine, oxindole, and pyrrolidine moieties were embedded in these novel bispirocyclic products, which will provide some support for the enrichment of chiral heterocyclic compound databases with potential medical value.
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