期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 6, 页码 3403-3408出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00068
关键词
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资金
- National Natural Science Foundation of China [21562024]
- Natural Science Foundation of Jiangxi Province [20161ACB21010]
- Science Fund for Distinguished Young Scholars in Jiangxi Province [20162BCB23023]
The synthesis of N-acyl-5-halo-8-aminoquino-lines has been realized by directly employing 8-aminoquino-lines and acyl halides (Cl, Br, I) with copper catalysis. The construction of the target products involves domino N-acylation and C5-H halogenations of the 8-aminoquinoline, wherein the acyl halides act as the donors of both acyl and halide atoms, which enables the first access to the step efficient synthesis of 5-halogenated N-acyl quinlolines.
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