期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 6, 页码 3378-3384出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.7b03215
关键词
-
资金
- SERB, India [ECR/2015/000600]
- IIT-R
Herein, we developed an operational simple, practical, and selective Ni-catalyzed synthesis of secondary amides. Application of renewable alcohols, earth-abundant and nonprecious nickel catalyst facilitates the transformations, releasing water as byproduct. The catalytic system is tolerant to a variety of functional groups including nitrile, allylic ether, and alkene and could be extended to the synthesis of bis-amide, antiemetic drug Tigan, and dopamine D2 receptor antagonist Itopride. Preliminary mechanistic studies revealed the participation of a benzylic C-H bond in the rate determining step.
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