期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 83, 期 11, 页码 6127-6132出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b00929
关键词
-
资金
- KAKENHI from Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan [15K05500]
- Grants-in-Aid for Scientific Research [15K05500] Funding Source: KAKEN
Alkyltitanium reagents, generated in situ from Grignard reagents and ClTi((OPr)-Pr-i)(3), can be employed without further manipulation in the enantioselective alkylation of aldehyde by the catalysis of a chiral titanium complex derived from DTBP-H-8-BINOL. The reaction is performed with good stoichiometry [1.5 equiv each of Grignard reagents and ClTi((OPr)-Pr-i)(3)] at a low catalyst loading (2 mol %), affording a variety of chiral secondary alcohols in high enantioselectivity and yields and, hence, realizing an asymmetric version of the Grignard reaction in an indirect manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据