期刊
PHYSIOLOGICAL RESEARCH
卷 63, 期 -, 页码 S1-S8出版社
ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
DOI: 10.33549/physiolres.932622
关键词
Spontaneously hypertensive rat; Recombinant inbred strains; Intermediary phenotypes; Transgenic; Gene targeting
类别
资金
- (ERC CZ program) from the Ministry of Education, Youth and Sports of the Czech Republic [LL1204, LH12061, LH11049]
- Czech Science Foundation [P303/10/0505, P301/10/0290, P301/12/0696, 13-04420S]
- Ministry of Health of the Czech Republic [NT/14325]
- Technological Agency of the Czech Republic [TA02010013]
The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and accompanying metabolic disturbances. Recent advances in sequencing of genomes of BN-Lx and SHR progenitors of the BXH/HXB recombinant inbred (RI) strains as well as accumulation of multiple data sets of intermediary phenotypes in the RI strains, including mRNA and microRNA abundance, quantitative metabolomics, proteomics, methylomics or histone modifications, will make it possible to systematically search for genetic variants involved in regulation of gene expression and in the etiology of complex pathophysiological traits. New advances in manipulation of the rat genome, including efficient transgenesis and gene targeting, will enable in vivo functional analyses of selected candidate genes to identify QTL at the molecular level or to provide insight into mechanisms whereby targeted genes affect pathophysiological traits in the SHR.
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