期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 58, 期 -, 页码 49-58出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2018.05.001
关键词
Gut microbiota; Barley leaf; Dietary fiber; Ferulic acid; Aromatic metabolites
资金
- Beijing Municipal Science and Technology Project Fund [D161100005416001]
- Chinese Universities Scientific Fund [2016SP003]
Barley leaf (BL) contains abundant plant fibers, which are important substrates for the metabolism and degradation by the gut microbiota. Here we show that mice fed a diet supplemented with BL exhibited altered gut bacterial composition characterized by the enrichment of fiber-degrading bacteria Lachnospiraceae and Prevotella. Gut microbiota-mediated BL degradation promoted butyrate and propionate production. Metabolomic analysis showed increased aromatic metabolites such as ferulic acid, 3-phenylpropanoic acid, 3-hydroxyphenylacetic acid and 3-hydroxyphenylpropionic acid in feces of mice fed with BL. Finally, antibiotic treatment and anaerobic fermentation confirmed the obligate role of gut microbiota in the production of aromatic metabolites during BL degradation. Together, these findings provide insights into a gut microbiota-mediated degradation process of BL fiber components, which results in the production of microbial-associated metabolites that may exert potential active effects on host physiology. (C) 2018 Published by Elsevier Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据