期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 57, 期 -, 页码 170-179出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2018.03.024
关键词
Obesity; miR-155; Epigenetic; Energy expenditure; Metabolism; Adipose tissue
资金
- Sao Paulo Research Foundation (FAPESP) [2013/22293-0, 2015/01316-7]
- National Council for Scientific and Technological Development (CNPq)
- Cruzeiro do Sul University
Obesity leads to changes in miRNA expression in adipose tissue, and this modulation is linked to the pathophysiology of the disease. Green tea (GT) is a natural source of polyphenols that have been shown to confer health benefits, particularly preventing metabolic diseases. Here, we investigated if the beneficial effects of GT in obesity results from changes in the miRNA profile in white adipose tissue. GT treatment [500 mg/body weight (BW)/12 weeks] increased energy expenditure of high-fat diet-fed mice (16 weeks), leading to reduced weight gain, decreased adiposity, reduced inflammation and improved insulin sensitivity. These phenotypes were associated with a decrease in the expression of miR-335 in the adipose tissue. miR-335 was up-regulated by TNF-alpha in adipocytes and, in turn, down-regulated genes involved in insulin signaling and lipid metabolism. On the other hand, GT inhibited TNF-a effect. In conclusion, miR-335 serves as a link between inflammation and impaired metabolism in adipose tissue, providing an important mechanistic insight into the molecular basis underlying GT action during obesity. (C) 2018 Elsevier Inc. All rights reserved.
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