期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 58, 期 -, 页码 1-16出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2018.02.012
关键词
Adipocytes; Fish oil; Metabolic syndrome; Obesity; Omega-3 polyunsaturated fatty acids; Weight loss
资金
- National Institutes of Health NCCIH [1 R15 AT008879-01A1]
- National Institute of Food and Agriculture, U.S. Department of Agriculture, AFRI [2017-67011-26029]
- NIFA [914532, 2017-67011-26029] Funding Source: Federal RePORTER
Strategies to reduce obesity have become public health priorities as the prevalence of obesity has risen in the United States and around the world. While the anti-inflammatory and hypotriglyceridemic properties of long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) are well known, their antiobesity effects and efficacy against metabolic syndrome, especially in humans, are still under debate. In animal models, evidence consistently suggests a role for n-3 PUFAs in reducing fat mass, particularly in the retroperitoneal and epididymal regions. In humans, however, published research suggests that though n-3 PUFAs may not aid weight loss, they may attenuate further weight gain and could be useful in the diet or as a supplement to help maintain weight loss. Proposed mechanisms by which n-3 PUFAs may work to improve body composition and counteract obesity-related metabolic changes include modulating lipid metabolism; regulating adipokines, such as adiponectin and leptin; alleviating adipose tissue inflammation; promoting adipogenesis and altering epigenetic mechanisms. (C) 2017 Elsevier Inc. All rights reserved.
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