期刊
GREEN CHEMISTRY
卷 17, 期 2, 页码 1071-1076出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4gc01728e
关键词
-
资金
- Universita degli Studi di Perugia
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) within program Firb-Futuro in Ricerca [N. RBFR08JKHI]
- project BIT3G - National Green Chemistry Cluster
gamma-Valerolactone (GVL) can be used as an efficient and practical alternative to the banned and commonly used dipolar aprotic solvents. In this contribution GVL has been used as a non-toxic, biodegradable, biomass-derived medium, for the definition of a simple and general protocol for the Sonogashira cross-coupling reaction. The chemical efficiency of GVL as a medium is excellent and the best results have been obtained using DABCO as the base allowing the isolation of products 3a-q in 60-96% yields. These results represent an example which proves that biomass-derived safer solvents can be used efficiently in common transformations reaching higher greenness/sustainability as well as high chemical efficiency.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据