期刊
GREEN CHEMISTRY
卷 17, 期 4, 页码 2339-2343出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4gc02203c
关键词
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资金
- CSIR
- ORIGIN Project [CSC-0108]
A novel, efficient, eco-friendly on water method has been developed for the Henry reaction of isatins with nitromethane to afford 3-hydroxy-3-nitromethylindolin-2-ones. An enhancement in reaction rate was observed on water under mild and catalyst-free conditions. This reaction tolerated a wide range of substrates with good to excellent product yields and is even applicable at large scales. Moreover, this method is environmentally friendly as it reduces the waste generated by the use of toxic solvents.
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