期刊
NATURE REVIEWS CANCER
卷 14, 期 5, 页码 342-357出版社
NATURE PORTFOLIO
DOI: 10.1038/nrc3691
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资金
- California Breast Cancer Research Program
- American Institute for Cancer Research and the Department of Defense Breast and Prostate Cancer Research Programs
- US National Institutes of Health (NIH) [DP2OD006740]
Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol, which has widespread actions throughout the body. Calcitriol regulates numerous cellular pathways that could have a role in determining cancer risk and prognosis. Although epidemiological and early clinical trials are inconsistent, and randomized control trials in humans do not yet exist to conclusively support a beneficial role for vitamin D, accumulating results from preclinical and some clinical studies strongly suggest that vitamin D deficiency increases the risk of developing cancer and that avoiding deficiency and adding vitamin D supplements might be an economical and safe way to reduce cancer incidence and improve cancer prognosis and outcome.
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