期刊
JOURNAL OF RADIOLOGY CASE REPORTS
卷 8, 期 5, 页码 1-8出版社
EDURAD
DOI: 10.3941/jrcr.v8i5.1721
关键词
Carbon monoxide poisoning; delayed post-ischemic encephalopathy; neurotoxicity syndromes; heroin inhalation syndrome; diffusion magnetic resonance imaging; magnetic resonance spectroscopy
Delayed leukoencephalopathy is an uncommon complication of hypoxic-ischemic events of different etiologies, including carbon monoxide intoxication. We present a case of a 40-year-old male patient who was admitted with rapidly progressive neurocognitive and behavioral deficits. There was a history of accidental carbon monoxide intoxication one month before, presenting with loss of consciousness and short hospitalization, followed by a complete clinical recovery. The imaging studies in the delayed phase depicted confluent, symmetric supra-tentorial white matter lesions in keeping with diffuse demyelinization. Restricted diffusion and metabolite abnormalities in magnetic resonance proton spectroscopy were also seen. The diagnosis of CO-mediated delayed post-hypoxic leukoencephalopathy was assumed after exclusion of other mimickers. Hyperbaric oxygen therapy was tentatively performed and the patient had a favorable clinical and radiological evolution.
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