期刊
GREEN CHEMISTRY
卷 17, 期 2, 页码 973-981出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4gc01469c
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资金
- Natural Science Foundation of Jiangsu Province [BK20131160]
- Natural Science Foundation of Jiangsu Higher Education Institutions [11KJB150014]
- Priority Academic Project Development of Jiangsu Higher Education Institutions
- Jiangsu College Graduate Research and Innovation Project of the Jiangsu Province Department of Education [KYZZ_0336]
A concise and efficient one-pot synthesis of functionalized [1,8] naphthyridine derivatives via a three-component domino reaction of glutaraldehyde, malononitrile, and beta-ketoamides, under catalyst-free conditions in an environmentally friendly medium (ethanol) is described. The main advantages of this protocol are short reaction times, practical simplicity, high yields, catalyst-free conditions, cheap and benign solvents, and high regio- and stereo-selectivities.
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