68Ga-DOTA and analogs: Current status and future perspectives

The construction of the Ge-68/Ga-68 generator has increased application of radiopharmaceuticals labeled with this isotope in medicine. Ga-68-PET is widely employed in the management of neuroendocrine tumors but favorable chemistry with tri-and tetraaza-ring molecules has opened wide range of Ga-68 application in other fields of PET imaging. This review covers the radiopharmaceuticals labeled with gallium in molecular imaging and shows perspectiveson the use of gallium-68 as a substitute for technetium-99, fluorine-18 and carbon-11 insome applications. (c) 2014 Greater Poland Cancer Centre. Published by Elsevier Urban & Partner Sp. zo.o. All rights reserved.