期刊
CLINICAL & TRANSLATIONAL IMMUNOLOGY
卷 3, 期 -, 页码 -出版社
WILEY
DOI: 10.1038/cti.2014.7
关键词
adoptive cell transfer; chimeric antigen receptor; gene therapy
类别
资金
- National Health & Medical Research Council of Australia (NHMRC) [1006188]
- Senior Research Fellowships from NHMRC
- Cancer Council of Victoria [1066554]
- Postdoctoral Fellowship from the National Breast Cancer Foundation of Australia
Immunotherapies are emerging as highly promising approaches for the treatment of cancer. In these approaches, a variety of materials are used to boost immunity against malignant cells. A key component of many of these approaches is functional tumor-specific T cells, but the existence and activity of sufficient T cells in the immune repertoire is not always the case. Recent methods of generating tumor-specific T cells include the genetic modification of patient lymphocytes with receptors to endow them with tumor specificity. These T cells are then expanded in vitro followed by infusion of the patient in adoptive cell transfer protocols. Genes used to modify T cells include those encoding T-cell receptors and chimeric antigen receptors. In this review, we provide an introduction to the field of genetic engineering of T cells followed by details of their use against cancer in the clinic.
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