期刊
NATURE REVIEWS CANCER
卷 14, 期 5, 页码 359-370出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3711
关键词
-
类别
资金
- NCI NIH HHS [R01 CA140875, R21 CA169673] Funding Source: Medline
p53 is a crucial tumour suppressor that responds to diverse stress signals by orchestrating specific cellular responses, including transient cell cycle arrest, cellular senescence and apoptosis, which are all processes associated with tumour suppression. However, recent studies have challenged the relative importance of these canonical cellular responses for p53-mediated tumour suppression and have highlighted roles for p53 in modulating other cellular processes, including metabolism, stem cell maintenance, invasion and metastasis, as well as communication within the tumour microenvironment. In this Opinion article, we discuss the roles of classical p53 functions, as well as emerging p53-regulated processes, in tumour suppression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据