期刊
JOURNAL OF NEURORADIOLOGY
卷 45, 期 5, 页码 265-275出版社
MASSON EDITEUR
DOI: 10.1016/j.neurad.2018.05.005
关键词
Inherited autosomal cerebellar ataxia; Dentate nuclei; Atrophy; Magnetic resonance imaging (MRI); Susceptibility-weighted imaging (SWI)
Ataxia is a neurodegenerative disease resulting from brainstem, cerebellar, and/or spinocerebellar tracts impairments. Symptoms onset could vary widely from childhood to late-adulthood. Autosomal cerebellar ataxias are considered as one of the most complex group in neurogenetics. In addition to their genetic heterogeneity, there is an important phenotypic variability in the expression of cerebellar impairment, complicating the genetic mutation research. A pattern recognition approach using brain MRI measures of atrophy, hyperintensities and iron-induced hypointensity of the dentate nuclei, could be therefore helpful in guiding genetic research. This review will discuss a pattern recognition approach that, associated with the age at disease onset, and clinical manifestations, may help neuroradiologists differentiate the most frequent profiles of ataxia. (C) 2018 Elsevier Masson SAS. All rights reserved.
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