期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 318, 期 -, 页码 97-102出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.02.013
关键词
Mycobacterium avium subsp paratuberculosis; Epstein-Barr virus; Neuromyelitis optica spectrum disorder; MBP; IRF5; AQP4
Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratubercutosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF5(424-434)) in multiple sclerosis (MS), we investigated whether seroreactivity to these antigens display a NMOSD-specific pattern. The sera of 34 NMOSD patients showed elevated levels of antibodies against MAP and MBP compared to healthy controls (44% vs. 5%, p < 0.0002 and 50% vs. 2%, p < 0.0001, respectively), while, unlike in MS, responsiveness to EBV was similar.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据