期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 323, 期 -, 页码 49-52出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.07.007
关键词
Mycobacterium avium ssp paratuberculosis; Signal transduction; Virulence factors; Neuromyelitis optica spectrum disorder; Multiple sclerosis; Astrocyte
Mycobacterium avium ssp. paratuberculosis (Map) is the etiological agent of Paratuberculosis in ruminants. Protein tyrosine phosphatase A (PtpA) and protein kinase G (PknG) are secreted proteins necessary for the survival of the pathogen within macrophages. In this study we analyzed if Map was able to grow within astrocytes and investigated on the presence of antibodies against PtpA and PknG proteins in MS and NMOSD patients by ELISA. Map was unable to proliferate in astrocytes after of 72 h post-infection, but we observed a high level of antibodies against both virulence factors, suggesting that these patients have been exposed/infected with Map.
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