期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 319, 期 -, 页码 9-12出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.03.011
关键词
Multiple sclerosis; Natalizumab; Rebound; Epstein-Barr virus; Virus-specific CD8+T lymphocytes; Immune reconstitution inflammatory syndrome
资金
- Italian Ministry of Health [RF-2011-02347228]
- FISM - Fondazione Italiana Sclerosi Multipla [2016/R/27]
- 5 per mille public fund
Studying rebound mechanisms in MS patients after interruption of natalizumab may advance our understanding of MS pathogenesis. To verify the role of Epstein-Barr virus (EBV) infection and anti-EBV immunity in post-natalizumab rebound, we analyzed postmortem brain tissue of a case of fatal MS relapse. Using lmmunohisto-chemistry, EBV latent, early and late lytic proteins and CD8+ T cells sticking to EBV lytically-infected cells were detected in multiple inflammatory white matter lesions. Using the pentamer technology on brain sections, EBV-specific CD8+ T cells were observed perivascularly. Cell-free EBV DNA was detected in cerebrospinal fluid. These findings confirm and extend the results obtained in another case of post-natalizumab fatal MS relapse, suggesting that this condition represents an EBV-associated immune reconstitution inflammatory syndrome.
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