期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 321, 期 -, 页码 164-170出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.05.003
关键词
Myasthenia gravis; LOMG; microRNA; miR-150-5p; MGC
资金
- Swedish Research Council [VR-523-2014-2048]
There are no biomarkers for late onset myasthenia gravis (LOMG; onset > 50 years). We evaluated circulating microRNA in a discovery cohort of 4 LOMG patients and 4 healthy controls and in a prospective diagnostic validation cohort of 73 LOMG patients (48 male) with longitudinal follow-up samples. In immunosuppression naive patients, levels of miRNAs miR-150-5p, miR-21-5p and miR-30e-5p decreased in parallel with clinical improvement after initiation of immunosuppression and their levels positively correlated with the clinical MG composite score. Levels of miR-150-5p and miR-21-5p were lower in patients with ocular compared to generalized LOMG. Circulating miR-150-5p, miR-21-5p and miR-30e-5p correlate with the clinical course in LOMG.
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