期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 323, 期 -, 页码 19-27出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.07.001
关键词
Multiple sclerosis; Cerebrospinal fluid; Beta2-microglobulin; Lactate; Angiotensin-converting enzyme; Age
资金
- Novartis [MFTY720A_FVSP003]
We compared cerebrospinal fluid levels of lactate, beta 2-microglobulin and angiotensin-converting enzyme (ACE) between 438 untreated patients with multiple sclerosis and 276 patients with non-inflammatory neurological disorders. Age-adjusted beta 2-microglobulin and lactate were significantly higher and ACE was significantly lower in MS patients than in controls. beta 2-microglobulin and ACE positively correlated with high significance both in MS patients and controls. While disease duration negatively correlated and progression index, defined as EDSS score divided by disease duration in years, positively correlated with age-adjusted lactate levels, both did neither correlate with beta 2-microglobulin nor with ACE. Both CSF beta 2-microglobulin and ACE deserve further investigation as biomarkers of multiple sclerosis pathophysiology.
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