期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 317, 期 -, 页码 24-31出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.02.007
关键词
Inflammatory cytokines; Chemokines; Cognitive function; Peripheral blood mononuclear cells (PBMCs); Monocyte-derived macrophages (MDMs); Glycolysis; Metabolism; PFKFB3
资金
- Government of Ireland Postgraduate Scholarship (Irish Research Council) [GOIPG/2013/331]
- Science Foundation Ireland [15/iA/3052]
- Science Foundation Ireland (SFI) [15/IA/3052] Funding Source: Science Foundation Ireland (SFI)
Identification of a blood-based biomarker that can detect early cognitive decline presents a significant healthcare challenge. We prepared peripheral blood mononuclear cells (PBMCs) from individuals who had a poorer than predicted performance in their delayed recall performance on the Logical Memory II Subtest of the Wechsler Memory Scale (WMS) relative to their IQ estimated by the National Adult Reading Test (NART); we described these individuals as IQ-discrepant, compared with IQ-consistent, individuals. Stimulation with A beta + LPS increased production of TNF alpha to a greater extent in cells from IQ-discrepant, compared with IQ-consistent, individuals. This was associated with a shift towards glycolysis and the evidence indicates that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB)3 plays a role in driving glycolysis. A similar shift towards glycolysis was observed in MDMs prepared from IQ-discrepant, compared with IQ-consistent, individuals. The important finding here is that we have established an increased sensitivity to A beta + LPS stimulation in PBMCs from individuals that under-perform on a memory task, relative to their estimated premorbid IQ, which may be an indicator of early cognitive decline. This may be a useful tool in determining the presence of early cognitive dysfunction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据